CE6 is formulated with unique complexes to support the male endocrine system and healthy male aging, including a complex to modulate and regulate testosterone production at the gene level, an endocrine and antioxidant support complex, heart health support, and lastly a gut microbiome and Nano2 Delivery Technology to ensure ingredient absorption, detoxification, and a healthy balanced bacterial biome*.
D-aspartate (DA) is the active form of the amino acid aspartic acid. DA has been shown to play a regulatory role in endocrine and neuroendocrine function and the regulation of the reproductive system.
DA is involved in several steps of steroidogenesis, regulating synthesis and release of sex steroid hormones including luteinizing hormone (LH), follicle-stimulating hormone (FSH) and growth hormone (GH). It may also build up in the testicles, where it can influence the rate limiting step of testosterone synthesis, leading to slight increases in free testosterone levels.
Shilajit is a mineral pitch, found in the Himilayan and Hindukush Mountain ranges at high altitudes and has traditional uses in Ayurveda medicine as a vitality enhancer and adaptogen. Shilajit is mostly a mixture of humic acids, with plant microbial metabolites. It has been suggested that Shilajit supplementation may help enhance strength, energy, testosterone levels as well as improve muscle adaptation.
After 8-weeks of shilajit supplementation, the retention of maximal muscular strength following the fatiguing protocol, showed a decrease in biomarkers of collagen degradation. Showing, favorable muscle and connective tissue adaptations.
In a study on healthy male volunteers a positive effect of shilajit on testosterone levels was observed. In a randomized, double blind, placebo-controlled study, men between 45 and 55 received shilajit for 90-days. Treatment with Shilajit had a significant effect, increasing total testosterone, free testosterone, and dehydroepiandrosterone (DHEAS).
Phosphatidylserine (PS) is a glycerophospholipid and is a major component of the cell membrane. PS accounts for 13 to 15% of the phospholipids in the brain. It’s also concentrated in organs with high metabolic activity such as the lungs, heart, liver, and skeletal muscle14.
PS modulates the activity of receptors, ion channels, enzymes and signaling molecules and is involved in governing membrane fluidity. PS forms part of protein docking sites necessary for the activation of several key signaling pathways.
.Modulation of the PS level in the plasma membrane of neurons has a significant impact on these signaling processes and may help improve cognitive function and the body’s ability to deal with stress. In recent studies, PS has been shown to enhance wellbeing during mental stress brought on by exercise, help speed up post-workout recovery, prevent muscle soreness, improve performance and accuracy for sports.
DHEA is an endogenous steroid, hormone precursor, mainly secreted by the adrenal cortex and the gonads, but also within the brain. DHEA and its sulfated metabolite, DHEAS, are the most abundant endogenous circulating steroid hormones in the body. It functions as metabolic intermediate in the biosynthesis of androgens including estrogens and testosterone, in the gonads and other tissues.
Decreased levels of DHEA are associated with aging and has been found in age-associated changes in cardiovascular tissues, fertility, metabolism, and neuronal/CNS functions.
DHEA may help alleviate symptoms associated with a decreased DHEA pool (either aging in which DHEA declines or adrenal insufficiency where DHEA synthesis declines) or it can be used to increase the DHEA pool and downstream metabolites, such as testosterone or estrogen for a short period of time.
Pregnenolone, is a naturally produced hormone in the body that is used as an antiinflammatory and analgesic, and for supporting cognitive function including improving memory, clarity and mood.
Pregnenolone is a steroid hormone precursor that is synthesized from cholesterol in steroidogenic tissues including the adrenal gland, gonads, and brain.
The mitochondria of these tissues are the sites for steroid hormone biosynthesis. When the adrenocorticotropic hormone (ACTH) is secreted, it stimulates the adrenal glands cortical region to produce cholesterol, which binds to the steroidogenic acute regulatory protein (StAR) in the outer membrane of the mitochondria.
Once inside the cell, the cytochrome enzyme P450 cuts the cortisol chain producing pregnenolone. This enzyme complex regulates the conversion of cholesterol to pregnenolone, regulating steroidogenesis.
Chaga, also known as Inonotus obliquus, is a parasitic fungus mainly of birch trees, and has numerous biological and medicinal properties, which have been commonly used in folk medicine in Northern Europe, China, Russia, and Korea, for a wide range of purposes.
Chaga is composed of various chemical components including polysaccharides, triterpenoids, polyphenols, beta-glucans, alpha-glucans, and melanin, it has been proven to possess anticancer, anti-inflammatory, anti-viral, antioxidant, hypoglycemic, and hypolipidemic activity.
Melanin, one of the active components from chaga, has been shown to be an effective prebiotic for the positive bifidobacteria development because of its ability to serve a variety of functions. Melanin contains proteins and polysaccharides; melanin can be used as an additional source of carbon and nitrogen for the bifidobacteria promoting a healthy gut microbiome.
Bacillus coagulans are a lactic acid, spore forming bacteria, known as a probiotic. Probiotics encourage the growth of ‘good’ or beneficial bacteria, this helps keep the harmful, ‘bad’ bacteria from over taking the gut. These good bacteria help encourage the production of immune cells and natural anti-bodies that can help bolster the immune system, reduce inflammation, and help improve nutrient absorption.
Bacillus coagulans have been shown to aid in the digestion of carbohydrates and protein, including increasing the absorption of key branched chain amino acids. This increased absorption has been associated with a reduction in muscle soreness and muscle damage, as well as an increase in recovery, strength, and power.
Policosanols are long-chain aliphatic alcohols found in sugar cane. The major phytochemical component is octacosanol. Policosanol can help reduce low density lipoprotein (LDL) cholesterol, triglycerides, platelet aggregation, endothelial damage, and smooth muscle cell proliferation, as well as raise high density lipoprotein (HDL). Policosanol can also inhibit cholesterol synthesis and enhance cholesterol degradation.
Studies have shown policosanol to be effective for lowering cholesterol, lowering blood pressure, and improving body composition, reducing body fat in humans.
Policosanol, has also been shown to increase brown adipose tissue activation (BAT), increasing fat oxidation and helping decrease body weight.
Fulvic acid is a group of diverse compounds known as humic substances, which are by-products of organic degradation from microorganisms. Fulvic acid consist of small molecular weight, hydrophilic, carboxylic-containing molecules including a mixture of covalently linked phenolic, quinoid and benzene carboxylic acid compounds.
Fulvic acid may work as both an anti-inflammatory and a pro-inflammatory helping reduce cytokine expression after exposure to toxins. Fulvic acid has also been shown to reduce COX2 and prostaglandin secretion.
Fulvic acid may also improve gut flora, nutrient, and mineral absorption in the gut. Fulvic acid binds to ingredients, increasing absorption across the intestine and into the blood, thus increasing bioavailability and delivery to target tissues.
An essential mineral needed in the diet, chromium has been shown to reduce food intake, body weight and increase glucose metabolism. The mechanism for chromium’s action is by improving the function of the glucose transporter GLUT-4, increasing translocation and up-take of glucose into fat cells via lowering plasma membrane cholesterol and mediating AMPK activation. Chromium also has action on the adiponectin hormone, which is released by fat tissue to help increase insulin sensitivity.
BerberineBerberine is a plant alkaloid extracted from Berberis vulgaris and has traditional uses in Chinese and Ayurvedic medicine for approximately the last 2500 years. It has shown to be effective for improving blood glucose disposal, improving insulin efficiency, lipid metabolism and body composition.
Berberine has been shown to regulate glucose and lipid metabolism, working on both fat cells and muscle cells inducing a variety of metabolic effects consistent with AMPK activation.
Berberine enhances insulin secretion, stimulates glycolysis (breakdown of sugar), suppresses adipogenesis (production of fat cells), activating AMPK pathway and increasing glycokinase (glucose regulation) activity.
Berberine, reduces intestinal glucose absorption, and up-regulates the expression of GLUT-4 translocation, stimulating glucose up-take, and upregulating glucagon like peptide (GLP-1) genes.
R-Alpha Lipoic AcidAlpha Lipoic Acid is a potent antioxidant, that acts as a cofactor involved in energy generation in the mitochondria of the cell. ALA has also been shown to reverse oxidative damage related to the effects of aging, assist in weight loss, appetite control and fat metabolism.
The metabolic action of ALA is mediated by activation of AMPK. ALA can regulate insulin secretion and sensitivity, mimic caloric surplus causing appetite suppression and regulating lipid metabolism.
ALA down-regulates key lipogenic enzymes, inhibiting lipogenesis and reducing triglyceride accumulation through the activation of AMPK signaling pathway in fat cells. ALA upregulates adiponectin expression in WAT (white adipose tissue), a key hormone involved in insulin sensitivity.
Gymnema sylvestreGymnema sylvestre is a plant used in traditional Ayurvedic medicine, for its therapeutic benefits when it comes to controlling blood sugar. Gymnema sylvestre has shown positive effects on blood sugar homeostasis, controlling sugar cravings, and promoting regeneration of the pancreas.
Gymnema sylvestre’s mode of action is through the stimulation in insulin secretion from the pancreas and by delaying glucose absorption in the blood. The main active component of Gymnema, gymnemic acids, has a chemical structure that fills the receptors in the taste buds but also in the intestines, preventing absorption of sugar. Gymnemic acids can also trigger insulin secretion and regeneration of islet cells of the pancreas enhancing up-take of glucose.
This process decreases glucose and fatty acid assimilation in the small intestine and interferes in the ability of receptors in mouth and intestine to the sensation of sweetness. Gymnemic acids may downregulate AMPK-mediated gluconeogenesis.
L-ErgothionenineL-ergothioneine (ET) is a thiol form of the natural amino acid histidine that can be considered an anti-aging, super antioxidant compound. Thiol-based antioxidants are considered the most powerful antioxidants in nature
In the body, ET is concentrated in cells and tissues frequently exposed to oxidative stress. It has also been shown that there are specific transporters for ET in the body, with abundant levels in tissues. ET transporters (ETT) move ET throughout the body, via the blood, storing it in locations that are high in free radical activity.
Cells lacking ETT are more susceptible to oxidative stress, resulting in increased mitochondrial DNA damage, protein oxidation, cytokine inflammatory response and lipid peroxidation. ET therefore acts as a strong antioxidant and anti-inflammatory compound. Additionally, it prevents lipid peroxidation and protects both mitochondria and DNA.
As a dietary supplement, take 2 capsules of AMPK Metabolic Activ8r two times daily. Take once before your first meal of the day, and once prior to bed on an empty stomach.
Do not use if the safety seal is broken or missing. It is not recommended for pregnant/nursing women. Consult a physician if taking medication (including insulin and oral diabetic medications) or have a medical condition. Keep out of reach children. Store in a cool, dry place after opening. Never exceed the recommended dose.
For best results, take AMPK two times daily. Take before your first meal of the day, and once prior to bed, on an empty stomach.
Can this product be combined with other BioGenix products?Yes, depending on your goals, AMPK Metabolic Activ8r can be combined with any BioGenix products to help meet your lifestyle goals.
Will AMPK Metabolic Activ8r help me to lose weight?AMPK is designed to help assist the metabolism, including help control appetite, blood sugar levels, and stimulate fat oxidation. For best results, AMPK should be combined with a reduced calorie diet and regular exercise program.
